Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi
These results should be considered when proposing the viability of dsx as a target gene for a population suppression gene drives in Anopheles stephensi. Although high homing rates were observed, the fitness defects found in both males and females carrying the transgene would likely prohibit this drive from functioning in the field.
Authors
- Michelle A. E. Anderson (ORCID: https://orcid.org/0000-0003-1510-2942)
- Lewis Shackleford (ORCID: https://orcid.org/0000-0002-8154-5154)
- Rob Noad (ORCID: https://orcid.org/0000-0002-0279-8461)
- Luke Alphey (ORCID: https://orcid.org/0000-0002-2916-3802)
- Katherine Nevard (ORCID: https://orcid.org/0000-0002-1008-6587)
- Estela González (ORCID: https://orcid.org/0000-0002-4296-0080)
- Philip T. Leftwich (ORCID: https://orcid.org/0000-0001-9500-6592)
- Joshua X. D. Ang (ORCID: https://orcid.org/0000-0002-4710-8831)
- Mireia Larrosa‐Godall (ORCID: https://orcid.org/0000-0003-1748-7815)
Institutions
- University of East Anglia (GB)
- The Pirbright Institute (GB)
- Royal Veterinary College (GB)
- Animal and Plant Health Agency (GB)
- University of York (GB)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13071-025-06688-0
- Citations
- 11
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 8.87
Funders
- Biotechnology and Biological Sciences Research Council