Evaluation of three novel antigens and costimulatory agents for improvement of M. Tuberculosis specific interferon gamma release assays
ACR, Rv1733 and Rv2626 failed to elicit equal or even better IFN-γ responses in our in-house IGRA compared to ESAT-6, CFP-10 and TB10.4 in patients with MT infection. The TLR9 agonist CpG ODN might be useful as co-stimulator in MT IGRAs.
Authors
- Victor Herbst
- Torsten Bauer (ORCID: https://orcid.org/0000-0003-1275-7361)
- Mark Reinwald (ORCID: https://orcid.org/0000-0002-6506-2136)
- Florian Hentschel (ORCID: https://orcid.org/0000-0003-2856-3940)
- Til R. Kiderlen (ORCID: https://orcid.org/0000-0003-3158-9527)
- Werner Dammermann (ORCID: https://orcid.org/0000-0001-6847-3769)
- Dorinja Zapf (ORCID: https://orcid.org/0000-0002-2449-0951)
- Sandra Schwarzlose-Schwarck
- David J. Krieger
- Stefan Lüth (ORCID: https://orcid.org/0000-0001-9946-0960)
Institutions
- Auguste-Viktoria-Klinik (DE)
- Helios Klinikum Emil von Behring (DE)
- Euroimmun Medizinische Labordiagnostika (Germany) (DE)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- Universitätsklinikum Brandenburg an der Havel (DE)
Publication Details
- Journal
- BMC Infectious Diseases
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12879-025-10577-3
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79