Efficacy of human umbilical cord mesenchymal stem cell in the treatment of neuromyelitis optica spectrum disorders: an animal study
Our results revealed that hUC-MSCs displayed therapeutic efficacy in NMOSD and showed potential in attenuating blood-brain barrier disruption, as well as AQP4 IgG and complement-induced astrocyte apoptosis.
Authors
- Xuzhong Pei
- Jie Ding (ORCID: https://orcid.org/0000-0002-0016-1141)
- Chunran Xue (ORCID: https://orcid.org/0000-0002-2817-1843)
- Yangtai Guan (ORCID: https://orcid.org/0000-0001-7322-6842)
- Haojun Yu (ORCID: https://orcid.org/0000-0002-9371-2773)
- Xiying Wang (ORCID: https://orcid.org/0000-0003-3312-9612)
- Xiaoying Yao (ORCID: https://orcid.org/0000-0001-6087-7996)
- Yi Chen (ORCID: https://orcid.org/0000-0001-5430-7612)
Institutions
- Shanghai University (CN)
- Renji Hospital (CN)
- Punan Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13287-025-04187-8
- Citations
- 3
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 4.88
Funders
- National Key Research and Development Program of China