Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis
The Smurf1-silenced MSCs' secretome shows potent osteogenic and anti-resorptive effects, significantly enhancing bone formation and reducing bone loss. This study provides compelling evidence for the therapeutic potential of Smurf1-silenced MSC-derived secretome as a non-toxic and targeted treatment for osteoporosis. These findings warrant further in vivo studies and clinical trials to validate its therapeutic efficacy and safety.
Authors
- Patricia Díaz‐Rodríguez (ORCID: https://orcid.org/0000-0002-7576-2013)
- María Isabel Pérez‐Núñez (ORCID: https://orcid.org/0000-0001-6423-260X)
- Alberto González-González (ORCID: https://orcid.org/0000-0002-2336-8284)
- Monica Dotta (ORCID: https://orcid.org/0000-0003-2719-0564)
- Ricardo Reyes (ORCID: https://orcid.org/0000-0002-1765-3257)
- Alfonso Bolado‐Carrancio (ORCID: https://orcid.org/0000-0003-2330-7489)
- Ana Alfonso-Fernández (ORCID: https://orcid.org/0000-0001-9513-261X)
- Flor M. Pérez-Campo (ORCID: https://orcid.org/0000-0002-9872-7990)
- Daniel García‐Sánchez (ORCID: https://orcid.org/0000-0002-1754-9185)
- Jesús Delgado‐Calle (ORCID: https://orcid.org/0000-0002-2083-2774)
- José C. Rodríguez‐Rey (ORCID: https://orcid.org/0000-0002-8369-3118)
- Itzíar Álvarez-Iglesias
Institutions
- Universidad de Cantabria (ES)
- Universidad de La Laguna (ES)
- Universidade de Santiago de Compostela (ES)
- Edinburgh Cancer Research (GB)
- Marqués de Valdecilla University Hospital (ES)
- Instituto de Investigación Marqués de Valdecilla (ES)
- Winthrop Rockefeller Foundation (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13287-025-04165-0
- Citations
- 2
- Primary Topic
- Connective Tissue Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Ministerio de Economía y Competitividad
- Instituto de Investigación Marqués de Valdecilla
- Instituto de Salud Carlos III