Loss of MEF2C function by enhancer mutation leads to neuronal mitochondria dysfunction and motor deficits in mice
Together, MEF2C dysregulation by the enhancer mutation leads to mitochondrial dysfunction and oxidative stress, which are prevalent features in motor neuronal damage and ALS pathogenesis. This genetic and epigenetic crosstalk mechanism provides insights for advancing our understanding of motor neuron disease and developing effective treatments.
Authors
- Yeyun Kim
- Ali Yousefian-Jazi (ORCID: https://orcid.org/0000-0002-6051-0235)
- Thor D. Stein (ORCID: https://orcid.org/0000-0001-6954-4477)
- Grewo Lim
- Hoon Ryu (ORCID: https://orcid.org/0000-0001-6544-3732)
- Hannah L. Ryu
- Kayeong Lim (ORCID: https://orcid.org/0000-0002-6274-7252)
- Hyewhon Rhim (ORCID: https://orcid.org/0000-0002-7600-7933)
- Hongik Hwang (ORCID: https://orcid.org/0000-0002-6363-9579)
- Jiyeon Chu
- Uiyeol Park
- Seung Jae Hyeon
- Suhyun Kim (ORCID: https://orcid.org/0000-0001-5006-3286)
- Min‐Gyeong Kim (ORCID: https://orcid.org/0000-0001-5313-9872)
- Kyung‐Eun Lee (ORCID: https://orcid.org/0000-0001-5112-7747)
- Phuong Thi Nguyen (ORCID: https://orcid.org/0009-0001-7894-1463)
- Seung-Hye Choi (ORCID: https://orcid.org/0000-0003-3957-4047)
- Jung-Hee Lee
Institutions
- Boston University (US)
- University of Seoul (KR)
- Kyung Hee Cyber University (KR)
- Yonsei University (KR)
- Korea University (KR)
- VA Boston Healthcare System (US)
- Kyung Hee University (KR)
- Korea Institute of Brain Science (KR)
- Korean Association Of Science and Technology Studies (KR)
- Bio-Medical Science (South Korea) (KR)
- Hanyang University (KR)
- Korea Institute of Science and Technology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Molecular Neurodegeneration
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s13024-024-00792-y
- Citations
- 3
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- National Research Foundation