Chitinase-3-like protein 1 (CHI3L1, YKL-40) in cardiovascular pathology

Cardiovascular diseases (CVD) represent a global medical, social, and economic issue. Currently, the search and study of new biological markers that can provide early diagnosis of CVD, serve as laboratory tools for assessing the effectiveness of treatment, or be used as prognostic markers and risk stratification criteria are ongoing. Scientists are particularly interested in studying chitinase-3-like protein 1 (CHI3L1, YKL-40) in relation to CVD. The precise role of CHI3L1 in both normal and pathological conditions remains unclear. Existing data suggest that CHI3L1 may regulate cell proliferation, differentiation, programmed cell death, as well as participate in embryonic development, angiogenesis, inflammatory responses, tissue remodeling, and a number of other processes. According to clinical studies conducted, CHI3L1 is a promising molecule with diagnostic and prognostic potential in CVD. The definitive confirmation of the role of CHI3L1 in cardiovascular pathology will be obtained through future research.