Aurora A Kinase Inhibition Is Synthetic Lethal With the Activation of MYCN in Retinoblastoma
Collectively, these findings demonstrate that AURKA is crucial for RB progression and further expanded the current understanding of synthetic lethal therapeutic strategies. Our study indicates that AURKA inhibitors may represent a new therapeutic strategy for selectively targeting patients with RB with RB1-deficient and MYCN-amplification to improve the prognosis of aggressive types of patients with RB.
Authors
- Xuyang Wen (ORCID: https://orcid.org/0000-0002-9794-4379)
- Qi-Li Liao (ORCID: https://orcid.org/0000-0002-4505-5617)
- Peiwei Chai (ORCID: https://orcid.org/0000-0002-9135-0940)
- Jiayan Fan
- Hanhan Shi (ORCID: https://orcid.org/0000-0001-9380-489X)
- Qianqian Zhang (ORCID: https://orcid.org/0000-0002-4422-4968)
- Jie Yang (ORCID: https://orcid.org/0000-0001-6235-1744)
- Shengfang Ge (ORCID: https://orcid.org/0000-0002-8005-2462)
- Renbing Jia
- Reyizha Mengjiang
- Xianqun Fan (ORCID: https://orcid.org/0000-0001-7442-1391)
- Yongyun Li (ORCID: https://orcid.org/0000-0001-8148-354X)
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai Ninth People's Hospital (CN)
- Shanghai Institute of Hematology (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1167/iovs.66.2.20
- Citations
- 4
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 4.61
Funders
- National Natural Science Foundation of China
- Shanghai Education Development Foundation
- Shanghai Municipal Education Commission