Favorable Outcome After Pegcetacoplan (Syfovre)-Associated Occlusive Retinal Vasculitis

An 86-year-old woman with advanced dry age-related macular degeneration developed occlusive retinal vasculitis 11 days after her first pegcetacoplan injection. Vision decreased from 20/30 to counting fingers. Vision improved to 20/200 with periocular and systemic steroids. Two different sets of culture plates and gram stains were all negative, but one thioglycolate broth had a light growth of <i>Staphylococcus epidermidis</i> and repeat vitreous culture broth grew a different organism (<i>Staphylococcus capitis</i>). After intravitreal steroids and ceftazidime, the vision ultimately improved to 20/20. Periocular and systemic steroids and antibiotics were associated with a favorable visual outcome in this patient. <b>[<i>Ophthalmic Surg Lasers Imaging Retina</i> 2025;56:170-173.]</b>.