Motor network reorganization associated with rTMS-induced writing improvement in writer's cramp dystonia
10 Hz rTMS to PSC improved writing dysfluency by redistributing motor network connectivity and strengthening somatosensory-parietal connectivity. A key signature for effective stimulation at PSC and improvement in writing dysfluency may be strengthening of intra-cortical connectivity between primary somatosensory and superior parietal cortices. These findings offer mechanistic hypotheses to advance the therapeutic application of TMS for dystonia.
Authors
- Noreen Bukhari‐Parlakturk (ORCID: https://orcid.org/0000-0001-9878-6459)
- Michael Fei (ORCID: https://orcid.org/0009-0001-0576-2413)
- Lysianne Beynel (ORCID: https://orcid.org/0000-0001-8670-7178)
- Andrew M. Michael
- Moritz Dannhauer (ORCID: https://orcid.org/0000-0001-8747-1021)
- Patrick J. Mulcahey (ORCID: https://orcid.org/0000-0002-3290-6769)
- B.L. Scott (ORCID: https://orcid.org/0000-0003-4608-4062)
- Chris Petty
- Pichet Termsarasab (ORCID: https://orcid.org/0000-0002-3260-3119)
- Simon W. Davis (ORCID: https://orcid.org/0000-0002-5943-0756)
- Angel V. Peterchev (ORCID: https://orcid.org/0000-0002-4385-065X)
- Hussein R. Al‐Khalidi (ORCID: https://orcid.org/0000-0003-1375-0487)
- Eleanor Wood (ORCID: https://orcid.org/0000-0001-8216-9544)
- Ziping Huang (ORCID: https://orcid.org/0000-0001-8251-5929)
- Michael William Lutz (ORCID: https://orcid.org/0000-0001-8809-5574)
- Nicole Calakos (ORCID: https://orcid.org/0000-0002-9918-3294)
- Lawrence G. Appelbaum (ORCID: https://orcid.org/0000-0002-3184-6725)
- Rabia Ghazi
- James T. Voyvodic
- S. Groves
- Mikaela Lipp
- Zeynep B. Simsek (ORCID: https://orcid.org/0009-0008-2044-4297)
- Tiffany K. Tran
Institutions
- Duke University (US)
- East Carolina University (US)
- Mahidol University (TH)
- University of California San Diego (US)
- Imaging, Brain, and Neuropsychiatry (FR)
- Ramathibodi Hospital (TH)
- Duke University Hospital (US)
- National Institute of Mental Health (US)
- Drexel University (US)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1016/j.brs.2025.02.005
- Citations
- 3
- Primary Topic
- Neurological disorders and treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.17
Funders
- Doris Duke Charitable Foundation
- Dystonia Medical Research Foundation
- American Academy of Neurology
- National Institute of Mental Health and Neurosciences
- National Center for Advancing Translational Sciences
- Dystonia Coalition