<i>rpoB</i> mutations and their association with rifampicin resistance in clinical <i>Staphylococcus epidermidis</i>
This study highlights the diverse genetic variants of rpoB associated with rifampicin resistance in clinical S. epidermidis isolates, including novel mutations. The strong correlation between mutational changes in RRDR and phenotypic resistance reinforces the role of rpoB mutations as a primary mechanism of resistance in clinical isolates.
Authors
- Karen Leth Nielsen (ORCID: https://orcid.org/0000-0002-7912-1985)
- Emeli Månsson (ORCID: https://orcid.org/0000-0003-2867-1044)
- Thor Bech Johannesen (ORCID: https://orcid.org/0000-0003-4502-7883)
- Frederik Boëtius Hertz (ORCID: https://orcid.org/0000-0003-0888-4616)
- Marc Stegger (ORCID: https://orcid.org/0000-0003-0321-1180)
- Sofie Marie Edslev (ORCID: https://orcid.org/0000-0002-8379-0145)
- Bo Söderquist (ORCID: https://orcid.org/0000-0001-5939-2932)
- Camille Kolenda (ORCID: https://orcid.org/0000-0002-3716-0521)
- Frédéric Laurent (ORCID: https://orcid.org/0000-0003-0609-9091)
- Mia Aarris (ORCID: https://orcid.org/0009-0001-7074-3219)
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Statens Serum Institut (DK)
- Uppsala University (SE)
- University of Copenhagen (DK)
- Murdoch University (AU)
- Örebro University (SE)
- Copenhagen University Hospital (DK)
- Rigshospitalet (DK)
- Hospices Civils de Lyon (FR)
- European Society of Clinical Microbiology and Infectious Diseases (CH)
- Centre International de Recherche en Infectiologie (FR)
- Mälardalen University (SE)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2025-01-28
- DOI
- https://doi.org/10.1093/jac/dkaf035
- Citations
- 2
- Primary Topic
- Antimicrobial Resistance in Staphylococcus
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- Gilead Sciences