Aggressive Management of Pulmonary Mucormycosis Necrotizing Fasciitis in a Post-Liver Transplant Patient

Pulmonary mucormycosis (PM) is a severe fungal infection that predominantly affects immunocompromised and diabetic individuals, and it is associated with a high mortality rate, particularly in cases of disseminated disease. We present the case of a 29-year-old liver transplant recipient who developed aggressive PM, confirmed through bronchoalveolar lavage. Treatment involved liposomal amphotericin B, followed by surgical debridement and right pneumonectomy. Despite these interventions, persistent infection required an Eloesser flap procedure for enhanced drainage. This case underscores the importance of early diagnosis and aggressive, multidisciplinary treatment approaches, including surgery and antifungal therapy, to improve outcomes in immunocompromised patients facing this life-threatening condition.

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Publication Details

Journal
Cureus
Published
2025-02-06
DOI
https://doi.org/10.7759/cureus.78649
Citations
1
Primary Topic
Antifungal resistance and susceptibility
Type
article
Field-Weighted Citation Impact
1.40
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article

Aggressive Management of Pulmonary Mucormycosis Necrotizing Fasciitis in a Post-Liver Transplant Patient

Ryan Hubbard, Srinivasa R. Chandra, Michael Bishop, Marc Moza
1 citations
Cureus
Antifungal resistance and susceptibility
1.40
article

Aggressive Management of Pulmonary Mucormycosis Necrotizing Fasciitis in a Post-Liver Transplant Patient

Ryan Hubbard, Srinivasa R. Chandra, Michael Bishop, Marc Moza
article en
1 citations

Abstract

Pulmonary mucormycosis (PM) is a severe fungal infection that predominantly affects immunocompromised and diabetic individuals, and it is associated with a high mortality rate, particularly in cases of disseminated disease. We present the case of a 29-year-old liver transplant recipient who developed aggressive PM, confirmed through bronchoalveolar lavage. Treatment involved liposomal amphotericin B, followed by surgical debridement and right pneumonectomy. Despite these interventions, persistent infection required an Eloesser flap procedure for enhanced drainage. This case underscores the importance of early diagnosis and aggressive, multidisciplinary treatment approaches, including surgery and antifungal therapy, to improve outcomes in immunocompromised patients facing this life-threatening condition.

CureusVol. 17(2)
Rush University Medical Center (US), A.T. Still University (US)
Good health and well-being
Openalex Percentile: Top 24%
Antifungal resistance and susceptibility
1.40
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