Roxadustat improves diabetic myocardial injury by upregulating HIF-1α/UCP2 against oxidative stress
FG-4592 exerts protective effects against diabetic myocardial injury by reducing oxidative stress. The mechanism is linked with the upregulation of HIF-1α and UCP2, which subsequently activate the PI3K/AKT/Nrf2 signaling pathway.
Authors
- Bing Yang (ORCID: https://orcid.org/0000-0003-4827-0926)
- Tingting Fang (ORCID: https://orcid.org/0000-0002-2441-2179)
- Luning Sun (ORCID: https://orcid.org/0000-0002-2470-4278)
- Ningning Zheng (ORCID: https://orcid.org/0000-0002-9728-2651)
- Congcong Ma (ORCID: https://orcid.org/0009-0003-6003-8289)
- Ming Zhao
Institutions
- Shenyang Medical College (CN)
- China Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12933-025-02601-2
- Citations
- 11
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 15.27
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Liaoning Province