Free fatty acids may regulate the expression of 11β-hydroxysteroid dehydrogenase type 1 in the liver of high-fat diet golden hamsters through the ERS-CHOP-C/EBPα signaling pathway
FFA may regulate the expression of hepatic 11β-HSD1 in high-fat-fed golden hamsters via the ERS-CHOP-C/EBPα signaling pathway, thereby affecting local corticosterone levels. Fenofibrate may downregulate the levels of 11β-HSD1 and corticosterone in local tissues by reducing FFA levels.
Authors
- Dandan Liu (ORCID: https://orcid.org/0009-0000-9938-1066)
- Kunjie Zheng
- Peipei Tian
- Guangyao Song (ORCID: https://orcid.org/0000-0002-9901-6074)
- Xiaoyu Hou (ORCID: https://orcid.org/0000-0001-5409-8785)
- Tingfu Zhang
- Chao Wang (ORCID: https://orcid.org/0000-0002-0415-503X)
- Lifang Liu (ORCID: https://orcid.org/0000-0003-1678-5511)
- Xiaolong Li (ORCID: https://orcid.org/0009-0004-6431-6036)
- Yilin Hou (ORCID: https://orcid.org/0000-0001-8876-2998)
Institutions
- Hebei Medical University (CN)
- Cangzhou Central Hospital (CN)
- Hebei General Hospital (CN)
- Harrison International Peace Hospital (CN)
- Baoding People's Hospital (CN)
Publication Details
- Journal
- Lipids in Health and Disease
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12944-025-02461-5
- Citations
- 2
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- National Natural Science Foundation of China