Stromal KITL/SCF Maintains Pancreas Tissue Homeostasis and Restrains Tumor Progression
By analyzing transcriptional programs in healthy and tumor-associated pancreatic mesenchyme, we find that a subpopulation of mesenchymal cells in healthy pancreas tissue expresses the paracrine signaling factor KITL. The loss of mesenchymal KITL is an accompanying and permissive feature of pancreas tumor evolution, with potential implications for cancer interception. See related article by Dolskii and Cukierman, p. 872.
Authors
- M. Kathrina Oñate (ORCID: https://orcid.org/0000-0003-3495-6038)
- Scott W. Lowe (ORCID: https://orcid.org/0000-0002-5284-9650)
- Mara H. Sherman (ORCID: https://orcid.org/0000-0001-7826-3888)
- Seung K. Kim (ORCID: https://orcid.org/0000-0001-6135-7810)
- Frank Arnold (ORCID: https://orcid.org/0000-0003-0025-3668)
- Sneha Pramod (ORCID: https://orcid.org/0000-0002-9282-3332)
- Yan Hang (ORCID: https://orcid.org/0000-0002-5166-2480)
- Yu-Jui Ho (ORCID: https://orcid.org/0000-0002-7540-024X)
- Sohinee Bhattacharyya (ORCID: https://orcid.org/0000-0001-6180-8415)
- Canping Chen (ORCID: https://orcid.org/0000-0003-4021-8592)
- Zheng Xia (ORCID: https://orcid.org/0000-0003-3364-8324)
- Chet Oon (ORCID: https://orcid.org/0000-0002-1494-6628)
- Vivien Low (ORCID: https://orcid.org/0000-0002-8561-011X)
- Xiaofan Zhao (ORCID: https://orcid.org/0000-0002-7286-7303)
- Ziqiao Yan
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Howard Hughes Medical Institute (US)
- Oregon Health & Science University (US)
- Cornell University (US)
- Stanford Medicine (US)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1079
- Citations
- 3
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.39