Alcohol Intake and Cardiometabolic Risk Factors Are Independently Associated With a Higher <scp>AST</scp>/Platelet Ratio Index in Obese Males

ABSTRACT It remains unclear whether alcohol intake and cardiometabolic factors are simultaneously associated with liver fibrosis progression in Japanese obese patients. This study investigated factors influencing liver fibrosis progression using the Aspartate Aminotransferase/Platelet Ratio Index (APRI), which does not include age. We conducted a cross‐sectional study of 26 737 obese (BMI ≥ 25 kg/m 2 ) adults undergoing health checkups. Steatotic liver disease (SLD) was diagnosed via ultrasonography. Clinical characteristics were analysed according to BMI category and APRI to identify risk factors for advanced liver fibrosis (APRI &gt; 1.0). The prevalence of type 2 diabetes, hypertension, and SLD increased with increasing BMI. On multivariable analysis in male, significant risk factors for advanced liver fibrosis included increased BMI (BMI 30–34.9 kg/m 2 : OR 2.64, 95% CI 1.89–3.69, p &lt; 0.001; BMI 35–39.9 kg/m 2 : OR 2.67, 95% CI 1.89–3.69, p = 0.002; BMI ≥ 40 kg/m 2 : OR 3.51, 95% CI 1.24–9.96, p = 0.018), SLD (OR 2.13, 95% CI 1.49–3.05, p &lt; 0.001), moderate alcohol intake (OR 1.36, 95% CI 1.03–1.79, p = 0.031), heavy alcohol intake (OR 4.31, 95% CI 2.90–6.40, p &lt; 0.001), high blood pressure (OR 1.30, 95% CI 1.01–1.67, p = 0.044), and high fasting blood glucose (OR 1.61, 95% CI 1.12–2.28, p = 0.008). In female, only age &gt; 65 years (OR 3.02, 95% CI1.93–4.73, p &lt; 0.001), BMI, and high uric acid (OR 2.06, 95% CI 1.15–3.68, p = 0.015) were extracted. In an obese male, alcohol intake and cardiometabolic factors were associated with liver fibrosis progression based on APRI, independent of elevated BMI and SLD.

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Publication Details

Journal
Liver international communications.
Published
2025-02-07
DOI
https://doi.org/10.1002/lci2.70010
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Alcohol Intake and Cardiometabolic Risk Factors Are Independently Associated With a Higher AST/Platelet Ratio Index in Obese Males

Atsushi Nakajima, Takumi Ohmura, Yoichi M. Ito, Miwa Kawanaka et al.
Liver international communications.
Liver Disease Diagnosis and Treatment
article

Alcohol Intake and Cardiometabolic Risk Factors Are Independently Associated With a Higher AST/Platelet Ratio Index in Obese Males

Atsushi Nakajima, Takumi Ohmura, Yoichi M. Ito, Miwa Kawanaka, Tsutomu Masaki, Tomoari Kamada, Tsubasa Tsutsumi, Tatsuji Maeshiro, Hitoshi Yoshiji, Hayashi Syokita, Hiroshi Sakugawa, Toshio Watanabe, Chitomi Hasebe, Yoshio Sumida, Koji Sawada, Kazufumi Okada, Yuichiro Eguchi, Yoshihiro Kamada, Miwa Tatsuta, Takaomi Kessoku, Takemi Akahane, Kanako Fuyama, Yoshioki Yoda, Hideki Fujii, Hiroshi Tobita, Masafumi Ono, Asahiro Morishita, Yuichiro Suzuki, Takumi Kawaguchi, Naoki Nishimoto, Nobuyuki Enomoto, Hirokazu Takahashi
article en

Abstract

ABSTRACT It remains unclear whether alcohol intake and cardiometabolic factors are simultaneously associated with liver fibrosis progression in Japanese obese patients. This study investigated factors influencing liver fibrosis progression using the Aspartate Aminotransferase/Platelet Ratio Index (APRI), which does not include age. We conducted a cross‐sectional study of 26 737 obese (BMI ≥ 25 kg/m 2 ) adults undergoing health checkups. Steatotic liver disease (SLD) was diagnosed via ultrasonography. Clinical characteristics were analysed according to BMI category and APRI to identify risk factors for advanced liver fibrosis (APRI &gt; 1.0). The prevalence of type 2 diabetes, hypertension, and SLD increased with increasing BMI. On multivariable analysis in male, significant risk factors for advanced liver fibrosis included increased BMI (BMI 30–34.9 kg/m 2 : OR 2.64, 95% CI 1.89–3.69, p &lt; 0.001; BMI 35–39.9 kg/m 2 : OR 2.67, 95% CI 1.89–3.69, p = 0.002; BMI ≥ 40 kg/m 2 : OR 3.51, 95% CI 1.24–9.96, p = 0.018), SLD (OR 2.13, 95% CI 1.49–3.05, p &lt; 0.001), moderate alcohol intake (OR 1.36, 95% CI 1.03–1.79, p = 0.031), heavy alcohol intake (OR 4.31, 95% CI 2.90–6.40, p &lt; 0.001), high blood pressure (OR 1.30, 95% CI 1.01–1.67, p = 0.044), and high fasting blood glucose (OR 1.61, 95% CI 1.12–2.28, p = 0.008). In female, only age &gt; 65 years (OR 3.02, 95% CI1.93–4.73, p &lt; 0.001), BMI, and high uric acid (OR 2.06, 95% CI 1.15–3.68, p = 0.015) were extracted. In an obese male, alcohol intake and cardiometabolic factors were associated with liver fibrosis progression based on APRI, independent of elevated BMI and SLD.

Liver international communications.Vol. 6(1)
Kurume University (JP), Asahikawa Medical University (JP), Saga University (JP), Kawasaki Medical School (JP), Kagawa University (JP), University of the Ryukyus (JP), Yamanashi Research Institute (JP), Heart Life Hospital (JP), Japanese Red Cross Asahikawa Hospital (JP), Hokkaido University Hospital (JP), Shimane University Hospital (JP), Nagoya Medical Center (JP), Asahikawa Kosei Hospital (JP), National Hospital Organization Takamatsu Medical Center (JP), Osaka Metropolitan University (JP), Kanagawa Dental University (JP), Nara Medical University (JP), University of Yamanashi (JP), Tokyo Metropolitan University (JP), International University of Health and Welfare (JP), Yokohama City University (JP), The University of Osaka (JP)
Kawasaki Medical School
Openalex Percentile: Top 96%
Liver Disease Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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