GGCT participates in the malignant process of hepatocellular cancer cells by regulating the PTEN/PI3K/AKT pathway through binding to EZH2
In conclusion, GGCT silencing restrained the proliferation and metastasis, and promoted apoptotic levels of HCC cells via regulating PTEN/PI3K/AKT pathway-mediated glycolysis, which might offer a prospective candidate in treating HCC.
Authors
- Yiming Yuan (ORCID: https://orcid.org/0000-0002-8312-0723)
- Junbo He
- Liangzhi Wang (ORCID: https://orcid.org/0000-0003-2282-4791)
- Mengjia Lv
Institutions
- Soochow University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1007/s12672-025-01882-z
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94