The protective role of SGLT2 inhibitors on aortic aneurysm mediated by oxidative stress and inflammation in type 2 diabetes mellitus
Our study suggested that patients using SGLT2i may have a lower risk of aortic aneurysm, and this effect could potentially be mediated by inflammation and oxidative stress. Further mechanistic and prospective studies are required to verify this association.
Authors
- Wenjuan Song (ORCID: https://orcid.org/0000-0003-1560-757X)
- Xiaotong Sun (ORCID: https://orcid.org/0000-0001-5628-0994)
- Mingyue Yuan (ORCID: https://orcid.org/0000-0002-8744-7133)
- Chengzhi Lu (ORCID: https://orcid.org/0000-0002-4546-6395)
- Rujie Zheng
- Jie Lu
Institutions
- Tianjin First Center Hospital (CN)
- Tianjin Nankai Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12933-025-02600-3
- Citations
- 6
- Primary Topic
- Diabetes Treatment and Management
- Type
- article
- Field-Weighted Citation Impact
- 7.77
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Tianjin City