Mural cell dysfunction contributes to diastolic heart failure by promoting endothelial dysfunction and vessel remodelling
Mural cell dysfunction contributes to HFpEF by inducing coronary vessel remodelling, at least in part by reducing EC proliferation and inducing EC inflammation through TNFα-dependent paracrine signalling.
Authors
- Bram Callewaert (ORCID: https://orcid.org/0000-0002-7473-1565)
- Mieke A. Dewerchin (ORCID: https://orcid.org/0000-0002-0382-9346)
- Steven J. Simmonds (ORCID: https://orcid.org/0000-0002-6750-5623)
- Peter Carmeliet (ORCID: https://orcid.org/0000-0001-7961-1821)
- Ümare Cöl (ORCID: https://orcid.org/0009-0008-3069-0598)
- Elizabeth A. V. Jones (ORCID: https://orcid.org/0000-0002-2006-7064)
- Stéphane Heymans (ORCID: https://orcid.org/0000-0001-9477-7803)
- Jana Raman (ORCID: https://orcid.org/0000-0002-3593-2735)
- Alessandra Pasut (ORCID: https://orcid.org/0000-0002-0895-4883)
- Mandy O. J. Grootaert (ORCID: https://orcid.org/0000-0003-1163-7499)
Institutions
- Khalifa University of Science and Technology (AE)
- Maastricht University (NL)
- VIB-KU Leuven Center for Cancer Biology (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12933-025-02623-w
- Citations
- 8
- Primary Topic
- Apelin-related biomedical research
- Type
- article
- Field-Weighted Citation Impact
- 11.16
Funders
- Dutch Cardiovascular Alliance
- European Commission
- Fonds Wetenschappelijk Onderzoek
- European Research Area Network on Cardiovascular Diseases
- Horizon 2020 Framework Programme