Escherichia coli combination with PD-1 blockade synergistically enhances immunotherapy in glioblastoma multiforme by regulating the immune cells
E. coli exhibits potential anti-tumor activity and can activate the innate immune response and further regulate immune cells in the tumor tissues to synergize the effect of anti-PD-1 therapy on GBM, providing new insights to enhance the efficacy of GBM immunotherapy.
Authors
- Xinyan Zhou (ORCID: https://orcid.org/0000-0002-3887-8121)
- Chengde Liao (ORCID: https://orcid.org/0000-0002-8891-7555)
- Haiyan Yang (ORCID: https://orcid.org/0000-0001-5185-4696)
- Guangrong Zheng (ORCID: https://orcid.org/0000-0002-8106-6663)
- Guochen Li (ORCID: https://orcid.org/0009-0009-1106-4345)
- Na Tan (ORCID: https://orcid.org/0000-0002-9177-5666)
- Xirui Duan
- Tengfei Ke (ORCID: https://orcid.org/0009-0002-7513-4997)
- Xiaolan Du (ORCID: https://orcid.org/0000-0001-5979-7999)
Institutions
- Chongqing University (CN)
- Peking University (CN)
- Kunming Medical University (CN)
- Peking University Cancer Hospital (CN)
- Yan'an Hospital Affiliated To Kunming Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12967-025-06194-y
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing Postdoctoral Science Foundation
- National Natural Science Foundation of China
- Kunming Medical University
- Natural Science Foundation of Chongqing
- Centre Scientifique et Technique du Bâtiment