Nigral Neuroinflammation and Dopaminergic Neurons in Parkinson's Disease and Atypical Parkinsonisms
The study reveals distinctive neuroinflammatory patterns in the SNc, with T cell-mediated inflammation prominent in PSP and microglia-mediated inflammation in PD. PSP and MSA show greater SNc dopaminergic neuron loss compared to PD. Increased neuroinflammatory response is seen in earlier disease stages, diminishing with greater neuron loss, which may inform disease progression understanding and therapeutic strategies. ANN NEUROL 2025;97:1096-1109.
Authors
- Per Borghammer (ORCID: https://orcid.org/0000-0001-6391-8052)
- Nadia Stefanova
- Tero J. Vahlberg (ORCID: https://orcid.org/0000-0002-4935-3056)
- Emmilotta A. Backman (ORCID: https://orcid.org/0000-0002-2733-5404)
- Gregor K. Wenning (ORCID: https://orcid.org/0000-0001-9077-1666)
- Valtteri Kaasinen (ORCID: https://orcid.org/0000-0002-3446-7093)
- Markus Peurla
- Maria Gardberg (ORCID: https://orcid.org/0000-0002-2179-4271)
- Laura Luntamo
Institutions
- Innsbruck Medical University (AT)
- University of Turku (FI)
- Aarhus University (DK)
- Aleksandër Moisiu University (AL)
- Turku University Hospital (FI)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Annals of Neurology
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1002/ana.27202
- Citations
- 17
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 23.62
Funders
- Päivikki ja Sakari Sohlbergin Säätiö
- Turun Yliopistollinen Keskussairaala
- Parkinsonfonden