Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis
Our study uncovers the importance of T cell EZH2 in human and mouse atherosclerosis. Inhibition of Ezh2 in CD4<sup>+</sup> T cells drives type 2 immune responses, resulting in an accumulation of iNKT2 and Th2 cells, memory T cells and anti-inflammatory macrophages that limit the progression of atherosclerosis.
Authors
- Wolfgang Enard (ORCID: https://orcid.org/0000-0002-4056-0550)
- Floriana Maria Farina (ORCID: https://orcid.org/0000-0002-5105-5672)
- Lars Mäegdefessel (ORCID: https://orcid.org/0000-0001-5228-2634)
- Aleksandar Janjic (ORCID: https://orcid.org/0000-0001-7180-5381)
- Menno P.J. de Winther (ORCID: https://orcid.org/0000-0002-4038-6636)
- Irem Avcilar-Kücükgöze (ORCID: https://orcid.org/0009-0006-7615-2969)
- Markus Joppich (ORCID: https://orcid.org/0000-0002-6665-8951)
- Michael Lacy (ORCID: https://orcid.org/0000-0001-5944-582X)
- Esther Lutgens (ORCID: https://orcid.org/0000-0002-2609-5744)
- Cecilia Assunta Bonfiglio (ORCID: https://orcid.org/0000-0002-7422-0503)
- Anuroop Venkateswaran Venkatasubramani (ORCID: https://orcid.org/0000-0003-2119-8741)
- Venetia Bazioti (ORCID: https://orcid.org/0000-0002-6076-5908)
- Katrin Nitz (ORCID: https://orcid.org/0009-0001-8528-5548)
- Dorothee Atzler (ORCID: https://orcid.org/0000-0002-6551-1544)
- Donato Santovito (ORCID: https://orcid.org/0000-0003-1811-4746)
- Axel Imhof (ORCID: https://orcid.org/0000-0003-2993-8249)
- Christian Weber (ORCID: https://orcid.org/0000-0003-4610-8714)
- Yuting Wu (ORCID: https://orcid.org/0000-0002-6308-4331)
- Vasiliki Triantafyllidou
- Mahadia Kumkum
- Yonara Freire Soares Marques
Institutions
- Mayo Clinic (US)
- Center for Integrated Protein Science Munich (DE)
- TUM Klinikum (DE)
- Karolinska Institutet (SE)
- Quantitative BioSciences (US)
- Munich Cluster for Systems Neurology (DE)
- Institute of Genetic and Biomedical Research (IT)
- Mayo Clinic in Arizona (US)
- German Centre for Cardiovascular Research (DE)
- Mayo Clinic in Florida (US)
- National Research Council (IT)
- Institute of Infection and Immunity (CA)
- Virginia Commonwealth University Medical Center (US)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Circulation
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1161/circulationaha.124.072384
- Citations
- 12
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 9.57
Funders
- Deutsches Zentrum für Herz-Kreislaufforschung
- Amsterdam University Medical Centers
- Deutsche Forschungsgemeinschaft
- Fondation Leducq
- ZonMw
- Bundesministerium für Bildung und Forschung
- Berlin Institute of Health
- National Institutes of Health
- Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers