Site-Selective Remote C4 Amination of 1-Naphthamides via Palladium–Single-Electron Transfer Catalysis
Achieving site-selective remote C-H amination of polycyclic aromatic hydrocarbons is a challenging yet exciting goal. Herein, we report the remote C4 amination of electron-deficient 1-naphthamides through a single-electron transfer strategy. This protocol features excellent functional group compatibility and does not require a chelating auxiliary.
Authors
- C Sivaraj (ORCID: https://orcid.org/0000-0001-9170-0827)
- Debabrata Maiti (ORCID: https://orcid.org/0000-0001-8353-1306)
- Sukumar Pradhan (ORCID: https://orcid.org/0000-0002-8882-6063)
- Thirumanavelan Gandhi (ORCID: https://orcid.org/0000-0002-0461-5155)
Institutions
- Indian Institute of Technology Bombay (IN)
- Vellore Institute of Technology University (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1021/acs.orglett.4c04858
- Citations
- 1
- Primary Topic
- Asymmetric Hydrogenation and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.54
Funders
- Council of Scientific and Industrial Research, India
- VIT University
- Science and Engineering Research Board