Comparative safety and efficacy of new-generation single-layer polytetrafluorethylene- versus polyurethane-covered stents in patients with coronary artery perforation for the RECOVER (REsults after percutaneous interventions with COVERed stents) Inve
New-generation single-layer polytetrafluorethylene (PTFE-) or polyurethane (PU-) covered stent (CS) for the treatment of coronary artery perforation (CAP) during PCI offer high procedural efficacy. To evaluate the comparative long-term safety and efficacy of both devices. This is a multicenter pooled analysis of individual data of patients with CAP undergoing implantation of single-layer PTFE-CS or PU-CS. Procedural endpoint was strategy success defined as successful placement of CS and sealing of perforation without surgical conversion. Clinical endpoints were mortality, myocardial infarction (MI), target vessel revascularization (TVR) and definite or probable stent thrombosis (def/prob ST) at 12 months. Seventy patients with CAP underwent implantation of two hundred eight CS, ninety-two PTFE-CS, and one hundred sixteen PU-CS. More than 1 stent was implanted in 13 patients (17.1%) in PTFE-CS group and 19 patients (20.2%) in PU-CS group, P = 0.80. Strategy success was high (96.1% versus 92.5%., P = 0.62). At 12 months, 71 patients (93.2%) in PTFE-CS group versus 79 patients (81%) in the PU-CS were alive, P = 0.05; TVR occurred in 14 patients (28.4%) in PTFE-CS group and 12 patients (17.9%) in PU-CS group, P= 0.54; MI in 1 patient (1.3%) in PTFE-CS group and 1 patients (1.1%) in PU-CS group, P = 0.86. Rates of def/prob ST were comparable 1.3% in PTFE-CS versus 3.1% in PU-CS P = 0.95. A strategy of implantation of a new-generation single-layer PTFE- or PU-CS for the treatment of coronary artery perforation showed high success rates. Both new-generation CS showed favorable and similar clinical safety, in particular with regard to thrombotic events.
Authors
- Adam Witkowski (ORCID: https://orcid.org/0000-0002-3514-2047)
- Holger Eggebrecht
- Jacques Monségu
- Wiktor Kuliczkowski (ORCID: https://orcid.org/0000-0001-6284-0820)
- Sebastian Kufner (ORCID: https://orcid.org/0000-0002-8091-4552)
- Jochen Wöhrle (ORCID: https://orcid.org/0000-0002-9915-1815)
- Stéphane Cook (ORCID: https://orcid.org/0000-0003-1221-2978)
- Christian Schlundt
- Benedikt Schrage (ORCID: https://orcid.org/0000-0001-9041-3922)
- Farrel Hellig
- Dirk Westermann (ORCID: https://orcid.org/0000-0002-7542-1956)
- Constantin von zur Mühlen (ORCID: https://orcid.org/0000-0003-2767-8009)
- Salvatore Cassese (ORCID: https://orcid.org/0000-0002-8668-4313)
- Ralf Birkemeyer
- Erion Xhepa (ORCID: https://orcid.org/0000-0002-0728-2819)
- Éric Eeckhout (ORCID: https://orcid.org/0000-0002-4784-1320)
- Nicolas Dumonteil
- Felix Voll (ORCID: https://orcid.org/0000-0003-1034-6147)
- Mirosław Ferenc (ORCID: https://orcid.org/0000-0002-1006-5014)
- Tomislav Miljak
- Heribert Schunkert
- Karl-Ludwig Laugwitz
- Adnan Kastrati
- Ludwig G. Strauss
- Michael Joner
- Göran Olivecronab
Institutions
- Universität Hamburg (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Lund University (SE)
- Centre Hospitalier Universitaire Vaudois (CH)
- TUM Klinikum (DE)
- Wroclaw Medical University (PL)
- Cardiovascular Center Bethanien (DE)
- Deutsches Herzzentrum der Charité (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- Groupe Hospitalier Mutualiste de Grenoble (FR)
- Klinikverbund Südwest (DE)
- German Centre for Cardiovascular Research (DE)
- Universitäts-Herzzentrum Freiburg-Bad Krozingen (DE)
- Institute of Cardiology (PL)
- Skåne University Hospital (SE)
- Clinique Pasteur (FR)
- Deutsches Herzzentrum München (DE)
- University Hospital Ulm (DE)
- Netcare Sunninghill Hospital (ZA)
Publication Details
- Journal
- Cardiovascular Intervention and Therapeutics
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1007/s12928-025-01084-y
- Citations
- 1
- Primary Topic
- Coronary Interventions and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Technische Universität München