Promoting ER stress in a plasmacytoid dendritic cell line drives fibroblast activation
Overall, our data suggest that ER stress induction in pDCs promotes fibroblast activation, which may contribute to the development of fibrosis in SSc.
Authors
- Inês S. Silva (ORCID: https://orcid.org/0000-0002-5935-8918)
- Adrienne W. Paton (ORCID: https://orcid.org/0000-0002-2996-5733)
- Catarina R. Almeida (ORCID: https://orcid.org/0000-0001-6670-6004)
- Beatriz H. Ferreira (ORCID: https://orcid.org/0000-0002-1497-7440)
- Iola F. Duarte (ORCID: https://orcid.org/0000-0003-4289-9256)
- James C. Paton (ORCID: https://orcid.org/0000-0001-9807-5278)
- Philippe Pierre (ORCID: https://orcid.org/0000-0003-0863-8255)
- Andreia Mendes (ORCID: https://orcid.org/0000-0003-1926-376X)
- Fátima Leite-Pinheiro (ORCID: https://orcid.org/0000-0002-8820-8062)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Shanghai Jiao Tong University (CN)
- Rede de Química e Tecnologia (PT)
- Centre d’Immunologie de Marseille-Luminy (FR)
- The University of Adelaide (AU)
- University of Aveiro (PT)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1186/s12964-025-02057-7
- Citations
- 4
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- National Institutes of Health
- Fundação para a Ciência e a Tecnologia