Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma
MEL-NPs demonstrated promising anti-melanoma properties, showing a selective cytotoxicity, a strong anti-invasive effect and a pro-apoptotic activity in CM cells, while inhibiting CAM angiogenesis, these novel findings contributing to future research on the potential application of this nanoplatform in CM therapy.
Authors
- Iasmina Marcovici (ORCID: https://orcid.org/0000-0003-3292-9079)
- Elena-Alina Moacă (ORCID: https://orcid.org/0000-0002-2631-7028)
- István Zupkó (ORCID: https://orcid.org/0000-0003-3243-5300)
- Adriana Ledeţi (ORCID: https://orcid.org/0000-0002-3462-1863)
- Raul Chioibaş (ORCID: https://orcid.org/0009-0004-1783-9109)
- Lucian Barbu–Tudoran (ORCID: https://orcid.org/0000-0003-0360-016X)
- Iulia Pînzaru (ORCID: https://orcid.org/0000-0003-2295-1926)
- Andreea Geamantan
- Cristina Adriana Dehelean
- Iasmina Predescu
Institutions
- University of Szeged (HU)
- Babeș-Bolyai University (RO)
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
- National Institute for Research and Development of Isotopic and Molecular Technologies (RO)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3389/fphar.2025.1487854
- Citations
- 6
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 4.84