Non-Surgical Healing of Large Endodontic Lesions Using a Novel Combination of Triple Antibiotics: A Report of 2 Cases

Background: Infections of the root canal system are typically polymicrobial. Due to their complexity, no single antibiotic can effectively sterilize the canal. Microorganisms re-accessing the pulp chamber or radicular space can cause primary or secondary infections, leading to endodontic pathosis. To avoid complications associated with surgical treatment of large endodontic lesions, conservative non-surgical approaches are recommended. Aim: This report aims to describe the healing of symptomatic large endodontic lesions through non-surgical management using a novel combination of triple antibiotics Methods and Material: Two cases of symptomatic large endodontic lesions were treated non-surgically with a novel combination of triple antibiotics. The approach focused on the disinfection of the root canal system to eliminate active intracanal microorganisms. Statistical Analysis: Follow-up radiographs were utilized to qualitatively assess the progressive healing of the endodontic lesions. Results: Follow-up radiographs of both cases showed progressive healing of the endodontic lesions. These findings suggest that surgical treatment is not always necessary for managing symptomatic large endodontic lesions. Conclusions: Even cyst-like periapical lesions can heal following conservative endodontic therapy with a novel combination of triple antibiotics, effectively eliminating active intracanal microorganisms through root canal system disinfection. Key words: Polymicrobial infection, Triple antibiotics, Non-surgical management, Endodontic lesions, Disinfection