C-reactive protein expression in acute ischemic stroke blood clots: Implications for etiology
Significantly more AIS clots of CE expressed substantial CRP compared to those of LAA and Crypt, suggesting CE strokes may be more strongly linked to inflammation. Clots with substantial CRP expression displayed significantly more fibrin compared to those with minimal CRP expression, suggesting a potential association between inflammation and fibrin-rich clots. Further study of the relationship between CRP, fibrin and WBCs in clots may improve our understanding of the processes of thrombo-inflammation.
Authors
- Ivan Vukašinović (ORCID: https://orcid.org/0000-0001-9396-5319)
- Guillaume Bellanger (ORCID: https://orcid.org/0000-0002-3642-904X)
- Vanessa Chalumeau (ORCID: https://orcid.org/0000-0002-7753-7186)
- Hirotoshi Imamura (ORCID: https://orcid.org/0000-0001-8923-7861)
- Jesús Juega (ORCID: https://orcid.org/0000-0003-1309-0730)
- Jean Darcourt (ORCID: https://orcid.org/0000-0003-1620-4449)
- Laurent Spelle (ORCID: https://orcid.org/0000-0002-6748-8528)
- Karen Doyle (ORCID: https://orcid.org/0000-0001-8984-6296)
- Nobuyuki Sakai (ORCID: https://orcid.org/0000-0002-3289-1210)
- Wenyi Liu (ORCID: https://orcid.org/0000-0002-5921-4674)
- Cansu Sahin (ORCID: https://orcid.org/0000-0001-5201-6619)
- Pierluca Messina (ORCID: https://orcid.org/0000-0003-0624-9926)
- Federico Sacchetti (ORCID: https://orcid.org/0000-0003-1276-0624)
- Anne-Christine Januel (ORCID: https://orcid.org/0000-0003-4910-6386)
- Nazan Güner Sak (ORCID: https://orcid.org/0000-0002-3172-1746)
- Marc Ribó (ORCID: https://orcid.org/0000-0001-9242-043X)
- Tsuyoshi Ohta (ORCID: https://orcid.org/0000-0001-9345-7701)
- Christophe Cognard (ORCID: https://orcid.org/0000-0003-4287-2627)
- Franz Bozsak
- Jorge Pagola (ORCID: https://orcid.org/0000-0002-0725-1369)
- Uroš Mirčić
- Predrag Stanarčević
- Alice Giraud
Institutions
- Hebron University (PS)
- Science Foundation Ireland (IE)
- Ollscoil na Gaillimhe – University of Galway (IE)
- University Hospital Galway (IE)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Clinique des Cèdres (FR)
- Laboratoire Ingénierie, Procédés, Aliments (FR)
- Univerzitetski Klinički Centar Srbije (RS)
- Vall d'Hebron Hospital Universitari (ES)
- University Clinical Centre (PL)
- COPE Galway (IE)
- Kobe City Medical Center General Hospital (JP)
- Bicêtre Hospital (FR)
Publication Details
- Journal
- European Stroke Journal
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1177/23969873251315636
- Citations
- 3
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- University of Galway
- Assistance Publique - Hôpitaux de Paris