The AMD-associated genetic polymorphism CFH Y402H confers vulnerability to Hydroquinone-induced stress in iPSC-RPE cells
Our findings suggest that the degree of cellular susceptibility to oxidative stress is not conferred by soluble FH protein and other complement sources, but intercellularly because of the corresponding genetic risk predisposition. Our data support the hypothesis that RPE cells carrying high genetic risk are less resilient to oxidative stress.
Authors
- Merve Sen (ORCID: https://orcid.org/0000-0002-5295-4493)
- Kapil Bharti (ORCID: https://orcid.org/0000-0003-4884-3173)
- Simon J. Clark (ORCID: https://orcid.org/0000-0001-8394-8355)
- Marius Ueffing (ORCID: https://orcid.org/0000-0003-2209-2113)
- Blanca Arango‐González (ORCID: https://orcid.org/0000-0002-9045-182X)
- Angela Armento (ORCID: https://orcid.org/0000-0002-6357-1500)
- Inga Sonntag
- Sylvia Bolz
- Ellen Kilger
- Ruchi Sharma (ORCID: https://orcid.org/0000-0002-2138-6462)
- Berta de la Cerda (ORCID: https://orcid.org/0000-0001-5603-6473)
- Rosario Fernandez-Godino
Institutions
- National Institutes of Health (US)
- University of Manchester (GB)
- National Eye Institute (US)
- Fundación Medina (ES)
- STZ eyetrial (DE)
- Centro Andaluz de Biología Molecular y Medicina Regenerativa (ES)
- University of Tübingen (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1527018
- Citations
- 4
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Deutsche Forschungsgemeinschaft
- Horizon 2020 Framework Programme