Targeting aldose reductase using natural African compounds as promising agents for managing diabetic complications
This study highlighted the potential inhibitory activity of 5 compounds that belong to the African region: (+)-Pipoxide, Zinc000095485961, Naamidine A, (-)-Pipoxide, and 1,6-di-o-p-hydroxybenzoyl-beta-d-glucopyranoside. These molecules inhibiting the aldose reductase, the key enzyme of the polyol pathway, can be developed as therapeutic agents to manage diabetic complications. However, we recommend <i>in vitro</i> and <i>in vivo</i> studies to confirm our findings.
Authors
- Omonijo Bukola
- George W. Hanson (ORCID: https://orcid.org/0000-0001-5792-8836)
- Olaitan Igbagbo Awe (ORCID: https://orcid.org/0000-0002-4257-3611)
- Toheeb A. Jumah
- Florence N. Mbaoji
- Mamadou Sangaré (ORCID: https://orcid.org/0000-0002-8300-8205)
- Miriam E. L. Gakpey
- Hedia Tebourbi
- Shadrack A. Aidoo
- Siyabonga Msipa
- Palesa C. Tjale
Institutions
- University of Nigeria (NG)
- University of Ghana (GH)
- African Institute for Mathematical Sciences (ZA)
- University of Cape Town (ZA)
- Noguchi Memorial Institute for Medical Research (GH)
- Université des Sciences, des Techniques et des Technologies de Bamako (ML)
- Université Mohammed VI Polytechnique (MA)
- Centre of Biotechnology of Sfax (TN)
- Ladoke Akintola University of Technology (NG)
Publication Details
- Journal
- Frontiers in Bioinformatics
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3389/fbinf.2025.1499255
- Citations
- 7
- Primary Topic
- Aldose Reductase and Taurine
- Type
- article
- Field-Weighted Citation Impact
- 8.06