Impact of sleep deprivation on colon cancer: Unraveling the KynA-P4HA2-HIF-1α axis in tumor lipid metabolism and metastasis
Our findings reveal that sleep deprivation impairs intracellular lipolysis by KynA, leading to lipid droplets accumulation in colon cancer cells. This process ultimately promotes colon cancer liver metastasis. This suggests a promising strategy for colon cancer treatment.
Authors
- Yuan Hu (ORCID: https://orcid.org/0000-0002-4460-5525)
- Xiaogang Shu (ORCID: https://orcid.org/0000-0002-7188-5892)
- Xukai Cheng
- Jinhuang Chen (ORCID: https://orcid.org/0000-0001-5987-2207)
- Jia Song (ORCID: https://orcid.org/0000-0002-5221-9915)
- Yongping Shi
- Wenzhong Zhu
- Feifei Fang (ORCID: https://orcid.org/0009-0009-3822-2905)
- Mi Jiang
- Zuojie Peng
- Haijun Bao (ORCID: https://orcid.org/0000-0001-6474-0540)
Institutions
- Union Hospital (CN)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1016/j.molmet.2025.102109
- Citations
- 5
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- National Natural Science Foundation of China