Elucidating the Role of HIF-1α/YAP Signaling Pathway in Regulating Inflammation in Human Periodontal Stem Cells: An in vitro Study
This study demonstrated that DMOG reduces inflammatory cytokine expression in hPDLSCs by stabilizing HIF-1α and activating the YAP signaling pathway. These findings provide a mechanistic basis for targeting the HIF-1α/YAP axis to control periodontal inflammation and support the potential of PHD inhibitors as therapeutic agents for periodontitis.
Authors
- S Liu
- X Y Wang
- Xuemei Zhang (ORCID: https://orcid.org/0000-0002-4979-6965)
- Xiang Ma (ORCID: https://orcid.org/0009-0001-4320-6928)
- Huzi Zhao (ORCID: https://orcid.org/0000-0001-8473-9627)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s504793
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00