The Aberrantly Expressed Nuclear Factor (Erythroid-derived 2)-Like 2 Participates in aGVHD by Modulating the Activation and Differentiation of CD4+ T Lymphocytes
Elevated NRF2 expression in CD4 + T cells of patients with aGVHD initiates and exacerbates aGVHD by potentiating T-cell activation, amplifying JAK1/STAT1 signaling, and instigating Th17/regulatory T-cell ratio imbalance.
Authors
- Yan Chen (ORCID: https://orcid.org/0000-0001-9311-6077)
- Tingting Cheng (ORCID: https://orcid.org/0000-0001-9452-6115)
- Yue Zhang (ORCID: https://orcid.org/0000-0002-6612-8002)
- Xu Chen (ORCID: https://orcid.org/0000-0003-4303-8116)
- Shiyu Wang (ORCID: https://orcid.org/0000-0001-8851-1697)
- Wei Qin
- Yajing Xu (ORCID: https://orcid.org/0000-0003-2847-2547)
Institutions
- Central South University (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Transplantation
- Published
- 2025-02-07
- DOI
- https://doi.org/10.1097/tp.0000000000005289
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China