High-dose thiamine supplementation ameliorates obesity induced by a high-fat and high-fructose diet in mice by reshaping gut microbiota
Our findings suggest that the potential mechanism by which high-dose thiamine supplementation alleviated HFFD-induced obesity might involve reshaping gut microbiota and restoring the intestinal barrier, thereby ameliorating gut microbiota-related endotoxemia.
Authors
- Weihong Ge (ORCID: https://orcid.org/0000-0001-5160-7855)
- Lulu Wang (ORCID: https://orcid.org/0000-0001-8079-4469)
- Yu Xia (ORCID: https://orcid.org/0000-0001-7647-4921)
- Yanyan Qiu
Institutions
- China Pharmaceutical University (CN)
- Nanjing Drum Tower Hospital (CN)
- Guangxi University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-02-07
- DOI
- https://doi.org/10.3389/fnut.2025.1532581
- Citations
- 5
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 5.82