Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis
In summary, this study pioneered the application of stromal cell enucleation technology to repair tissue damage in the reproductive system, explored the potential of cell burial in the treatment of reproductive system diseases and provided a new approach for the clinical treatment of male infertility.
Authors
- Jiancheng Wang (ORCID: https://orcid.org/0000-0001-9599-0171)
- Peng Huang (ORCID: https://orcid.org/0000-0002-0146-921X)
- Jiayu Huang (ORCID: https://orcid.org/0000-0001-5195-1330)
- Zehang Liang
- Lu Sun
- Baijun Dong (ORCID: https://orcid.org/0000-0001-7622-3946)
- Jiahong Wu (ORCID: https://orcid.org/0000-0001-8583-0414)
- Xishan Wang (ORCID: https://orcid.org/0000-0002-0471-3134)
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s12958-025-01352-9
- Citations
- 7
- Primary Topic
- Hormonal and reproductive studies
- Type
- article
- Field-Weighted Citation Impact
- 9.06
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- National Key Research and Development Program of China
- National Key Research and Development Program of China Stem Cell and Translational Research