Multiomics Analysis Reveals Therapeutic Targets for Chronic Kidney Disease With Sarcopenia
Our study is the first to establish a regulatory network of kidney-muscle crosstalk to explore the potential mechanism of CKD-related sarcopenia. Employing multiomics analysis, cellular assessment and animal experiments, we have identified that Spp1 could potentialy serve as a promising therapeutic target for CKD patients with sarcopenia.
Authors
- Meiqiu Wang (ORCID: https://orcid.org/0000-0002-8413-0392)
- Zhengkun Xia (ORCID: https://orcid.org/0000-0003-1443-9009)
- Lianghui You (ORCID: https://orcid.org/0000-0002-4313-6114)
- Jiaping Shu
- Chenbo Ji (ORCID: https://orcid.org/0000-0002-9869-4228)
- Lili Jia
- Chunlin Gao
- Xiaoyi Sun
- Ren Wang (ORCID: https://orcid.org/0000-0003-1317-6593)
- Zhiqiang Zhang (ORCID: https://orcid.org/0000-0002-5521-7579)
- Pei Zhang (ORCID: https://orcid.org/0009-0009-5063-3512)
- Xu He
- Yingchao Peng (ORCID: https://orcid.org/0009-0004-9036-8091)
Institutions
- Nanjing General Hospital of Nanjing Military Command (CN)
- Nanjing Maternity and Child Health Care Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- Jinling Institute of Technology (CN)
- Southeast University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of Cachexia Sarcopenia and Muscle
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/jcsm.13696
- Citations
- 8
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 9.31
Funders
- National Natural Science Foundation of China