Histological chorioamnionitis and its predictors among mothers with premature rupture of membranes delivering at tertiary hospitals in Uganda: a multicenter cross-sectional study

The prevalence of HCA in this study was notably higher than previously reported data from Uganda. Neutrophil infiltration was the most frequently observed histological lesion. Patients with PROM who were referred from other health facilities or had not attended PNC were at a higher risk of developing HCA. These findings highlight the critical need for early detection and management of HCA in mothers with PROM, particularly in resource-limited settings. Routine screening for HCA should be implemented for all women presenting with PROM, with special attention to referred cases and those without PNC. Early initiation of treatment should be considered until the diagnosis is definitively ruled out. Further research is needed to explore the underlying causes of HCA to inform targeted preventive measures.