Repeated-Dose Toxicity of Lauric Acid and Its Preventive Effect Against Tracheal Hyper-Responsiveness in Wistar Rats with Possible In Silico Molecular Targets
LA at 100 mg/kg has low toxicity, prevents hyper-responsiveness in an asthma model in rats, and acts as a multitarget compound with a good affinity for proteins related to airway hyper-responsiveness.
Authors
- Marianne M. Vieira
- José Luiz de Brito Alves (ORCID: https://orcid.org/0000-0003-4696-3809)
- Isabela Motta Felício (ORCID: https://orcid.org/0000-0002-1708-7339)
- Leticia Santos Gomes (ORCID: https://orcid.org/0000-0002-6045-5053)
- Natália Ferreira de Sousa (ORCID: https://orcid.org/0000-0001-7131-6414)
- Lucas Nóbrega de Oliveira (ORCID: https://orcid.org/0000-0003-2656-6910)
- Gabriel Nunes Machado de Oliveira (ORCID: https://orcid.org/0000-0001-7014-7612)
- Jayne Muniz Fernandes (ORCID: https://orcid.org/0000-0002-8686-8278)
- Daniele Idalino Janebro Ximenes
- Luciana Scotti (ORCID: https://orcid.org/0000-0003-1866-4107)
- Alissa Maria de Oliveira Martins
- Fabiana de Andrade Cavalcante (ORCID: https://orcid.org/0000-0002-5462-9459)
- Indyra Alencar Duarte Figueiredo
- Luiz Henrique César Vasconcelos (ORCID: https://orcid.org/0000-0003-0161-4891)
- Margareth de Fátima Formiga Melo Diniz (ORCID: https://orcid.org/0000-0001-9896-9044)
- Andréa Cavalcanti (ORCID: https://orcid.org/0000-0002-6947-9975)
- Marcus Tullius Scotti (ORCID: https://orcid.org/0000-0003-4863-8057)
- Igor Gabriel da Silva Ramalho
Institutions
- Universidade Federal da Paraíba (BR)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3390/ph18020221
- Citations
- 3
- Primary Topic
- Receptor Mechanisms and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Fundação de Apoio à Pesquisa do Estado da Paraíba
- Universidade Federal da Paraíba