Pre-transplant T-cell clonal analysis identifies CD8+ donor reactive clones that contribute to kidney transplant rejection
The findings of our study add to our understanding of T-cell alloreactivity following kidney transplantation and provide evidence for the role of pre-defined alloreactive T-cells in the development of allograft rejection.
Authors
- Jes M. Sanders (ORCID: https://orcid.org/0000-0001-7465-2480)
- Paul Fields (ORCID: https://orcid.org/0000-0002-9608-6464)
- Lorenzo Gallon (ORCID: https://orcid.org/0000-0002-6094-1027)
- Barbara L. Banbury (ORCID: https://orcid.org/0000-0001-7332-7117)
- Joseph R. Leventhal (ORCID: https://orcid.org/0000-0003-1604-9207)
- James M. Mathew (ORCID: https://orcid.org/0000-0002-5667-750X)
- Yuvaraj Sambandam (ORCID: https://orcid.org/0000-0002-5855-7085)
- Jie He (ORCID: https://orcid.org/0000-0001-6961-8421)
- E. Schumacher
Institutions
- Northwestern University (US)
- Adaptive Biotechnologies (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3389/fimmu.2025.1516772
- Citations
- 3
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.96
Funders
- U.S. Department of Defense
- Stryker
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases