Impaired Glymphatic Function in Acute Spontaneous Intracerebral Hemorrhage
The DTI-ALPS index, which reflects glymphatic functionality, is notably diminished on the ipsilateral side in acute sICH, correlating significantly with increased volumes of hemorrhage and edema. This study suggests that glymphatic dysfunction may contribute to the severity of clinical outcomes, and highlights the potential role of the glymphatic system in the pathophysiology of sICH.
Authors
- Ying Zhou (ORCID: https://orcid.org/0000-0003-3577-4527)
- Shenqiang Yan (ORCID: https://orcid.org/0000-0001-6425-0672)
- Mengmeng Fang
- Jinsong Cai
- Kai Wei (ORCID: https://orcid.org/0000-0001-7068-6114)
- Yanhui Dong (ORCID: https://orcid.org/0000-0003-2519-3200)
Institutions
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1111/cns.70252
- Citations
- 5
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 4.55
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province