Clinical Scaleup of Humanized AnnA1 Antibody Yielded Unexpected High Reticuloendothelial (RES) Uptake in Mice
The changes in the Fc region of hAnnA1-mut led to higher liver and spleen uptake, suggesting the antibody's recognition by the innate immune system (likely complement protein binding) and subsequent clearance. Future clinical translation using hAnnA1 and other antibodies needs to limit protein modifications that could drastically reduce blood clearance.
Authors
- Tim Buss
- Abdullah Metebi
- Satyendra Kumar Singh (ORCID: https://orcid.org/0000-0001-6795-670X)
- Kurt R. Zinn (ORCID: https://orcid.org/0000-0001-7463-4741)
- Chelsea Nayback
- Dalen Agnew (ORCID: https://orcid.org/0000-0001-8538-1348)
- Jan E. Schnitzer (ORCID: https://orcid.org/0000-0001-8211-9539)
- Lu Lucy Xu (ORCID: https://orcid.org/0000-0003-2753-4363)
Institutions
- Proteogenomics Research Institute for Systems Medicine (US)
- Michigan State University (US)
Publication Details
- Journal
- Antibodies
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3390/antib14010014
- Citations
- 1
- Primary Topic
- Cell Adhesion Molecules Research
- Type
- article
- Field-Weighted Citation Impact
- 1.62
Funders
- National Cancer Institute