Enantioselective Decarboxylative Hydrogen-Atom Transfer Reaction

Direct enantioselective decarboxylative transformations of carboxylic acids have become powerful tools for constructing structurally and functionally diverse molecules. Herein, an unprecedented organocatalyzed protocol for enantioconvergent decarboxylative reduction was established by leveraging dual catalysis of photoredox-mediated radical generation and a thiol-catalyzed asymmetric hydrogen-atom transfer process. With this hydrodecarboxylation, a variety of chiral 3-substituted indolines were attained from the acids in moderate to excellent yields with high enantioselectivities.