Antibiotic-Free Phototherapy via an Indocyanine Green-Decorated Gold Nanoparticle/Manganese Dioxide Nanocomposite
Phototherapy treatment, as an alternative to antibiotic therapy, promises to be a noninvasive strategy to treat bacterial infections with a low likelihood of inducing bacterial resistance. However, the prolonged high temperature induced by photothermal therapy (PTT) and the limited reactive oxygen species (ROS) yield generated by photodynamic therapy (PDT) still limit clinical application. Here, we overcome the limitations of current PTT and PDT technologies through the effect of the red-shifted local surface plasmon resonance (LSPR) and oxygen vacancies to synthesize an indocyanine green-decorated gold nanoparticle/manganese dioxide (APIM) nanocomposite, improving photothermal stability and ROS generation. Under 808 nm laser irradiation, APIM nanocomposites achieved antibacterial efficiencies of up to 99.9% against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli and 99% against tetracycline-resistant E. coli EIEC. Furthermore, the near-infrared (NIR)-mediated APIM nanocomposite could effectively treat S. aureus-infected wound in vivo without marked toxicity. Overall, synergistic PTT and PDT utilizing the APIM nanocomposite may provide a promising treatment for skin wound infection.
Authors
- Zheyu Li (ORCID: https://orcid.org/0000-0002-0022-3189)
- Shuai Xiang (ORCID: https://orcid.org/0000-0003-1566-2106)
- Saulius Juodkazis (ORCID: https://orcid.org/0000-0003-3542-3874)
- Kai Sun (ORCID: https://orcid.org/0000-0003-3359-4274)
- Xu Shi (ORCID: https://orcid.org/0000-0002-6353-5470)
- Suyao Yin (ORCID: https://orcid.org/0009-0002-5745-0777)
- Denver P. Linklater (ORCID: https://orcid.org/0000-0003-1433-3685)
- Dongmei Li (ORCID: https://orcid.org/0000-0003-3819-355X)
- Lei Jiang (ORCID: https://orcid.org/0000-0003-4579-728X)
- Elena P. Ivanova (ORCID: https://orcid.org/0000-0002-5509-8071)
- Liping Wen (ORCID: https://orcid.org/0000-0001-8546-8988)
- Shuai He
- Zhanguo Zong (ORCID: https://orcid.org/0000-0001-9259-4296)
- Zechang Li
Institutions
- The University of Melbourne (AU)
- Chinese Academy of Sciences (CN)
- Harbin Institute of Technology (CN)
- Hokkaido University (JP)
- Clark Art Institute (US)
- MIT University (MK)
- Creative Research (GB)
- Optical Sciences (United States) (US)
- Technical Institute of Physics and Chemistry (CN)
- Great Minds in STEM (United States) (US)
- Swinburne University of Technology (AU)
- RMIT University (AU)
Publication Details
- Journal
- ACS Applied Nano Materials
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1021/acsanm.4c07031
- Citations
- 7
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 4.72
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Heilongjiang Province