Exosomes and their distinct integrins transfer the characteristics of oxaliplatin- and 5-FU-resistant behaviors in colorectal cancer cells
Our findings reveal that, despite discrepancies between cellular integrin patterns and cellular behaviors, the levels of exosomal ITGβ3, ITGαv, or ITGβ4 could serve as potential diagnostic and therapeutic markers for resistance to oxaliplatin and 5-FU in future cancer treatments.
Authors
- Amir Shadboorestan (ORCID: https://orcid.org/0000-0002-5695-8934)
- Mohammad Hossein Ghahremani (ORCID: https://orcid.org/0000-0001-5051-6214)
- Elahe Motevaseli (ORCID: https://orcid.org/0000-0002-3237-298X)
- Roxana Sahebnasagh (ORCID: https://orcid.org/0009-0000-8111-4197)
- Hoda Deli
- Zeynab Vakili-Ghartavol
Institutions
- Tarbiat Modares University (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1186/s10020-025-01110-y
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Science Foundation
- Iran National Science Foundation
- Tehran University of Medical Sciences and Health Services