Synthesis and Anti-Inflammatory Evaluation of Novel Hybrids of 7-Oxodehydroabietic Acid Bearing a 1,2,3-Triazole Moiety
To discover novel, potent anti-inflammatory diterpenoids, a series of hybrids of 7-oxodehydroabietic acid bearing a 1,2,3-triazole moiety was designed and synthesized. The target compounds were characterized by means of <sup>1</sup>H NMR, <sup>13</sup>C NMR, and ESI-HRMS. All the compounds were evaluated for their anti-inflammatory activity towards BV2 cell lines using L-NMMA (IC<sub>50</sub> = 42.36 ± 2.47 µM) as a positive control. Most showed good anti-inflammatory activities, especially compounds <b>10</b> (IC<sub>50</sub> = 8.40 ± 0.98 µM), <b>15</b> (IC<sub>50</sub> = 10.74 ± 2.67 µM), <b>16</b> (IC<sub>50</sub> = 10.96 ± 1.85 µM), and <b>17</b> (IC<sub>50</sub> = 9.76 ± 1.27 µM), which exhibited potent anti-inflammatory effects on BV2 cell lines.
Authors
- Han Luo (ORCID: https://orcid.org/0000-0002-9498-6290)
- Fang Cheng-wu
- Fu‐Cai Ren (ORCID: https://orcid.org/0000-0002-8685-9283)
- Wen-Tao Fang
- Dong-mei Xie (ORCID: https://orcid.org/0000-0001-8491-3939)
- Shou‐Jin Liu
- Hong Zhang (ORCID: https://orcid.org/0000-0002-8585-5838)
- Yong-Feng Lv
- Xiaobo Zhang (ORCID: https://orcid.org/0009-0005-0532-6100)
Institutions
- Kunming Institute of Botany (CN)
- Anhui Medical University (CN)
- Chinese Academy of Sciences (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Westlake University (CN)
Publication Details
- Journal
- Molecules
- Published
- 2025-02-06
- DOI
- https://doi.org/10.3390/molecules30030750
- Primary Topic
- Biological Activity of Diterpenoids and Biflavonoids
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Anhui University
- Anhui University of Chinese Medicine