Biologically active peloids as monotherapy in patients with chronic abacterial prostatitis

BACKGROUND: Chronic prostatitis is the most prevalent condition among male reproductive system disorders. The treatment of chronic prostatitis has not only medical but also significant social implications. AIM: To evaluate the efficacy of a biogenic complex containing Tambukan mud in patients with chronic abacterial prostatitis. MATERIALS AND METHODS: The study included 67 patients aged 28 to 57 years diagnosed with chronic abacterial prostatitis. All patients received a biogenic complex containing Tambukan mud in the form of suppositories, administered twice daily for 15 days. The total follow-up period was 1 month, with clinical evaluations conducted during the initial visit, on Day 15 (second visit), and on Day 30 (third visit). RESULTS: Analysis of patient-reported outcomes using the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) revealed that the total score decreased from 25.9 ± 3.8 to 3.9 ± 0.11 during treatment. Palpation of the prostate gland showed improvement: in all 67 patients (100%), the prostate became elastic, and in 63 patients (94%), it became non-tender. Transrectal ultrasound findings at the second visit demonstrated an average prostate volume reduction of 1.3 times, which further decreased to 1.5 times by the third visit. At the third visit, there was a statistically significant increase in both peak systolic and diastolic blood flow velocities in the central and peripheral zones of the prostate compared to baseline (p 0.001). CONCLUSIONS: The findings indicate that a biogenic complex containing Tambukan mud has a beneficial effect on the key clinical manifestations of chronic abacterial prostatitis. It significantly reduces pain and urinary symptoms, decreases prostate volume, restores prostatic hemodynamics, and may be recommended for this patient population.