Photothermal Conjugated Polymer Microneedle with Biofilm Elimination and Angiogenesis for Diabetic Wound Healing
Diabetic wounds are highly susceptible to bacterial infection, which can lead to the formation of bacterial biofilms, making diabetic wound healing a major challenge. In this study, a composited microneedle that incorporated drug-loaded conjugated polymer nanoparticles and basic fibroblast growth factor was prepared to eliminate biofilms and promote vascular regeneration. This microneedle released minocycline under near-infrared (NIR) light, effectively penetrating bacterial biofilms. The photothermal properties of the conjugated polymers, combined with the antibacterial action of minocycline, contribute to the eradication of biofilms and the elimination of drug-resistant bacteria. Moreover, it regulated the wound microenvironment by reducing the level of oxidative stress, as well as the production of inflammatory factors at the wound site. Meanwhile, it effectively boosted cell migration and promoted angiogenesis to accelerate diabetic wound healing. This composited microneedle for biofilm elimination represents a promising approach for promoting diabetic wound healing.
Authors
- Wentai Li (ORCID: https://orcid.org/0000-0002-7463-9566)
- Zijuan Wang (ORCID: https://orcid.org/0000-0002-7683-5392)
- Shuyi Qu (ORCID: https://orcid.org/0009-0004-2903-7867)
- Qi Shao (ORCID: https://orcid.org/0000-0002-9858-0458)
- Chengfen Xing (ORCID: https://orcid.org/0000-0002-1939-2265)
- Chenyao Nie (ORCID: https://orcid.org/0000-0001-7785-6198)
- Hao Li (ORCID: https://orcid.org/0000-0002-4151-0707)
- Jie Li (ORCID: https://orcid.org/0000-0001-7163-3778)
- Jian Xiao (ORCID: https://orcid.org/0000-0001-7374-6506)
- Xin Zhang (ORCID: https://orcid.org/0000-0003-2484-2424)
- Ran Zhang (ORCID: https://orcid.org/0000-0003-2319-6774)
- Boying Li (ORCID: https://orcid.org/0000-0001-7616-080X)
Institutions
- Hebei University of Economics and Business (CN)
- Hebei University of Technology (CN)
- Wenzhou Medical University (CN)
- Biomedical Research Institute (US)
Publication Details
- Journal
- Nano Letters
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1021/acs.nanolett.4c06284
- Citations
- 25
- Primary Topic
- Advancements in Transdermal Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 19.77
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Hebei Province
- Hebei Provincial Department of Bureau of Science and Technology
- National Key Research and Development Program of China