Anti-nephrin autoantibodies in steroid-resistant nephrotic syndrome may inform treatment strategy
The prevalence of anti-nephrin antibodies is substantially higher in children with steroid responsive NS than in those with SRNS, suggesting that anti-nephrin antibodies primarily drive SSNS/SDNS. In contrast, NS due to podocyte gene mutations is primarily genotype-caused. Anti-nephrin autoantibodies may serve as a positive prognostic marker in pediatric NS, indicating a favorable response to immunosuppressive therapy.
Authors
- Alev Yılmaz (ORCID: https://orcid.org/0000-0003-1743-1491)
- Fatih Özaltın (ORCID: https://orcid.org/0000-0003-1194-0164)
- Franz Schaefer
- Aysun Karabay Bayazıt (ORCID: https://orcid.org/0000-0002-2644-5628)
- Felicitas E. Hengel (ORCID: https://orcid.org/0000-0003-4899-414X)
- Julien Hogan (ORCID: https://orcid.org/0000-0003-4838-9417)
- Dušan Paripović (ORCID: https://orcid.org/0000-0003-2091-8890)
- Francesco Emma (ORCID: https://orcid.org/0000-0002-0383-3468)
- Nicola M. Tomas (ORCID: https://orcid.org/0000-0002-6385-9862)
- Marina Vivarelli (ORCID: https://orcid.org/0000-0002-2448-1959)
- Tobias B. Huber (ORCID: https://orcid.org/0000-0001-7175-5062)
- Silke Dehde
- Pierre Ronco
Institutions
- Universität Hamburg (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Sorbonne Université (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- University Medical Center Hamburg-Eppendorf (DE)
- Bambino Gesù Children's Hospital (IT)
- Centre Hospitalier du Mans (FR)
- Hôpital Robert-Debré (FR)
- University Children's Hospital, Belgrade (RS)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Cukurova University (TR)
- Hacettepe University (TR)
- Istanbul University (TR)
Publication Details
- Journal
- Kidney International
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1016/j.kint.2025.01.019
- Citations
- 26
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 37.20
Funders
- Deutsche Forschungsgemeinschaft
- Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie
- H2020 European Research Council