SARS-CoV-2 spike treatment and transfection impairs airway epithelial repair
SARS-CoV-2 spike S1 treatment and transfection can alter measures of proliferation and inflammation as well as impair wound closure of 16HBE14o- airway epithelial cells. These results highlight how components of SARS-CoV-2 can impair functions of the airway epithelium independent of viral replication.
Authors
- Tony Ju Feng Guo
- Gurpreet K. Singhera (ORCID: https://orcid.org/0000-0002-8422-0857)
- Wan Yi Liang (ORCID: https://orcid.org/0000-0002-3401-4262)
- Jasmine Memar Vaghri
- Janice M. Leung (ORCID: https://orcid.org/0000-0003-1682-6483)
- Del Dorscheid
Institutions
- University of British Columbia (CA)
- St. Paul's Hospital (CA)
Publication Details
- Journal
- ERJ Open Research
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1183/23120541.00940-2024
- Primary Topic
- Respiratory Support and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- St. Paul's Foundation