Vincristine Regulates C/EBP-β/TGF-β1 to Promote A1 Astrocyte Polarization and Induce Neuropathic Pain
Vincristine induced spinal cord inflammation by promoting A1 polarization of astrocytes via upregulating the C/EBP-β/TGF-β1 signal pathway, thus leading to neuropathic pain. It was different from the traditional signal pathway, this study shown a new signal pathway for astrocyte A1 polarization, which may provide a possibility for clinical treatment of neuropathic pain.
Authors
- Yunfu Chen (ORCID: https://orcid.org/0009-0008-2305-8850)
- Jing Shi (ORCID: https://orcid.org/0000-0002-9687-8592)
- Chao Chen (ORCID: https://orcid.org/0000-0001-7374-8755)
- Lijian Pei (ORCID: https://orcid.org/0000-0001-7174-9105)
- Xinglong Xiong
- Sijie Tang (ORCID: https://orcid.org/0000-0001-6588-1855)
- Jun Lu (ORCID: https://orcid.org/0009-0008-8365-6668)
- Guangling Tang
Institutions
- Guiyang Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/dddt.s504873
- Citations
- 4
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 4.66
Funders
- National Natural Science Foundation of China
- Guizhou Medical University