Photoredox-Catalyzed Allylic C–H Fluorosulfonylation of Alkenes: Accessing Allyl Sulfonyl Fluorides
This study reported a novel and unprecedented photoredox-catalyzed protocol for direct allylic C-H fluorosulfonylation of alkenes with FABI. This mild protocol exhibited excellent compatibility with various functional groups, broad substrate scope, and promising scalability, enabling convenient access to a wide range of allyl sulfonyl fluorides with exceptional regioselectivity. The synthetic robustness of this strategy was further demonstrated by the late-stage functionalization of natural products and their ligation with other drugs via SuFEx chemistry.
Authors
- Zhi-Min Yan
- Qi Lin (ORCID: https://orcid.org/0000-0002-3786-3593)
- Wei Li (ORCID: https://orcid.org/0000-0001-5069-5945)
- Chunfang Zhang (ORCID: https://orcid.org/0000-0003-0768-0531)
- Jiahua Yang (ORCID: https://orcid.org/0000-0003-2144-309X)
- Yichen Dong (ORCID: https://orcid.org/0000-0003-2280-4248)
- Lijin Wang
- Hua Li
- Yu-Xue Ma
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Hebei University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-02-06
- DOI
- https://doi.org/10.1021/acs.orglett.5c00015
- Citations
- 5
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- Natural Science Foundation of Hebei Province
- Hebei University
- Hebei Provincial Department of Bureau of Science and Technology